The reference site for Repaglinide

Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus.

WHAT IS REPAGLINIDE?

Repaglinide is commonly used in people with type 2 (non-insulin-dependent) diabetes. It is administered alone or with other medications to control high blood sugar levels, together with a proper diet and exercise program.

Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and decreased sexual ability.

This medication works by lowering blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the beta cells. This depolarizes the beta cells, opening the cells’ calcium channels, and the resulting calcium influx induces insulin secretion.

Repaglidine is sold under the brand name of Prandin® in the US, GlucoNorm® in Canada, and NovoNorm® elsewhere.

 

Brand Name(s): Prandin; GlucoNorm; NovoNorm
CAS nº: 135062-02-1
(reh PAG lih nide)

 

Product Info

The sections below will provide you with more specific information and guidelines related to repaglinide and its correct use. Please read them carefully.

FDA Information

Precursor drugs to repaglinide were invented in late 1983 by scientists at Dr. Karl Thomae GmbH, a German drug manufacturer located at Biberach an der Riß in southern Germany, which was subsequently acquired by Boehringer Ingelheim in 1990.

The drug that became repaglinide was later licensed by Boehringer to Novo Nordisk, which filed an Investigational New Drug application for the compound with the Food and Drug Administration in April 1992. Following this, Novo Nordisk filed its New Drug Application (NDA) for Prandin® in July 1997 and it was quickly approved, gaining final FDA approval in December 1997.

The drug was the first of the meglitinide class. It was branded Prandin® because its quick onset and short duration of action concentrates its effect around meal time (the prandium was the Roman meal which is comparable to the modern lunch).

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Repaglinide is commonly used in people with type 2 (non-insulin-dependent) diabetes. It is administered alone or with other medications to control high blood sugar levels, together with a proper diet and exercise program.

Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, circulation problems, and decreased sexual ability.

This medication works by lowering blood glucose by stimulating the release of insulin from the pancreas. It achieves this by closing ATP-dependent potassium channels in the membrane of the beta cells. This depolarizes the beta cells, opening the cells’ calcium channels, and the resulting calcium influx induces insulin secretion.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Repaglinide comes as an oral tablet, and should be taken with a full glass of water 15 minutes before each meal. However, it can be taken immediately before a meal or up to 30 minutes before a meal.

Repaglinide may be taken 2-4 times a day. Take this medication exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

If you skip a meal, skip the repaglinide dose for that meal, unless otherwise directed by your doctor. If you add a meal or significantly more food to your diet than usual, ask your doctor if you may need an additional dose of repaglinide.

What special precautions should I follow?

BEFORE TAKING REPAGLINIDE:

Tell your doctor if you have kidney disease, liver disease, Type 1 diabetes mellitus (insulin-dependent diabetes), diabetic ketoacidosis, a serious infection, illness, or injury, or if you require surgery. You may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Moreover, please inform your doctor if you are taking any of the following medicines: aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid®, others), diflunisal (Dolobid®), choline salicylate-magnesium salicylate (Trilisate®, Tricosal®, others), or magnesium salicylate (Magan®, Mobidin®, Doan’s®, others); a beta-blocker such as atenolol (Tenormin®), metoprolol (Lopressor®, Toprol XL®), propranolol (Inderal®), and others; a diuretic (water pill) such as hydrochlorothiazide (HCTZ®, HydroDiuril®) and others; a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan®), phenelzine (Nardil®), and tranylcypromine (Parnate®); a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Advil®, Motrin®, Nuprin®, others), naproxen (Aleve®, Anaprox®, Naprosyn®, others), ketoprofen (Orudis KT®, Orudis®, Oruvail®), and others; a phenothiazine such as chlorpromazine (Thorazine®), perphenazine (Trilafon®), and thioridazine (Mellaril®); a steroid medication such as prednisone (Deltasone®, others), methylprednisolone (Medrol®, others), dexamethasone (Decadron®, others), and prednisolone (Prelone®, others); a sulfa-based drug such as sulfamethoxazole (Bactrim®, Septra®, others); a thyroid medication; birth control pills or estrogen replacement therapy; erythromycin (E-Mycin®, Ery-Tab®, E.E.S.®, others); ketoconazole (Nizoral®) or itraconazole (Sporanox®); phenobarbital (Luminal®) or mephobarbital (Mebaral®); phenytoin (Dilantin®, Phenytek®); probenecid; rifampin (Rifadin®, Rimactane®); or warfarin (Coumadin®).

The medications listed above may interact with repaglinide or affect blood sugar control. You may require a dosage adjustment or special monitoring during treatment.

Do not take any over-the-counter cough, cold, allergy, pain, or weight-loss medications without first talking to your doctor. These medications may contain sugar or alcohol or affect blood sugar levels.

Drugs other than those listed here may also interact with repaglinide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Repaglinide is in the FDA pregnancy category C. This means that it is not known whether this medicine will be harmful to an unborn baby. Do not take this medicine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Furthermore, it is not known whether this medicine passes into breast milk. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

Follow diet, medication, and exercise routines very closely. Changing any of these routines can affect blood sugar levels.

Additionally, try to avoid alcohol consumption. It lowers blood sugar and may interfere with diabetes treatment.

Please inform your doctor and dentist that you are taking this medication before having any form of surgery.

What should I do if I forget a dose?

If you forget to take a dose until after you have eaten, skip that dose and take only the next regularly scheduled dose. Please note that this medication should always be taken before a meal.

What side effects can this medication cause?

Stop taking repaglinide and seek emergency medical attention if you experience an allergic reaction such as:

difficulty breathing
closing of the throat
swelling of the lips, tongue, or face
hives

The side effects of treatment with repaglinide result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency.

Low blood sugar may occur if meals are missed or delayed after taking a dose of repaglinide, if you exercise more than usual, during illness, especially with vomiting or diarrhea, if you take other medications, after drinking alcohol, and in other situations. Hypoglycemia, or low blood sugar, has the following symptoms:

hunger
headache or nausea
drowsiness
weakness or dizziness
fast heartbeat
sweating
tremor

Keep sugary hard candy, chocolate, fruit juice, or glucose tablets on hand to treat episodes of low blood sugar.

Increased blood sugar
may occur if you eat significantly more food than usual, if you exercise less than usual, if you take other medications, if you have a fever or other illness, and in other situations. Hyperglycemia, or high blood sugar, has the following symptoms:

increased thirst
increased hunger
increased urination

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Please remember to throw away any medication that is outdated or no longer needed. If you have any questions, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, then please call the local emergency services on 911.

Symptoms of a repaglinide overdose include:

hunger
nausea
anxiety
cold sweats
weakness
drowsiness
unconsciousness
coma

 

Product Images

PICTURES OF REPAGLINIDE PILLS

Below you will find images and specific information on the principal types of repaglinide that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PRANDIN®
Strength(s): 1 MG
Imprint: LOGO
Manufacturer: NOVO NORDISK

Name: PRANDIN®
Strength(s): 2 MG
Imprint: LOGO
Manufacturer: NOVO NORDISK

Name: PRANDIN®
Strength(s): 1 MG TABLET
Imprint: MEDLEY
Manufacturer: MEDLEY

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